By Ben VerbruggeShareNewsweek is a Trust Project memberThe San Francisco 49ers (7-4) host the Carolina Panthers (6-5) on Monday Night Football in a key battle for NFC playoff positioning.
How to Watch Carolina Panthers vs San Francisco 49ers
- When: Monday, November 24, 2025
- Time: 8:15 PM ET
- TV Channel: ESPN, ESPN Deportes, ESPN2
- Live Stream: Fubo (try for free)
San Francisco comes into the game in the seventh and final playoff position in the NFC thanks to a tiebreaker advantage over the Detroit Lions. The 49ers come off a 41-22 road win over the Arizona Cardinals last week in which Brock Purdy threw three touchdown passes, and Christian McCaffrey scored three, two on the ground and one via the air, while George Kittle caught a pair of touchdown throws. San Francisco played turnover-free football for just the second time this season in the win. Linebacker Tatum Bethune (ankle) and kicker Eddy Piñeiro (hamstring) are out for Monday night, with linebacker Robert Beal (concussion) listed as doubtful and linebacker Luke Gifford (hip) questionable.
The Panthers are ninth in the NFC playoff standings but can claim a half-game lead over the Tampa Bay Buccaneers in the NFC South with a victory on Monday night. Carolina lost the lead late in regulation before Ryan Fitzgerald kicked a 28-yard field goal in overtime to deliver a 30-27 road win over the Atlanta Falcons last week. Bryce Young threw for 448 yards and three touchdowns, with Tetairoa McMillan catching eight passes for 130 yards and two scores. The team won’t have center Cade Mays (ankle) or linebackers Christian Rozeboom (hip) and Trevin Wallace (shoulder) against the 49ers.
The game marks the first time McCaffrey will face Carolina since the October 2022 trade that sent him from the Panthers to San Francisco. The 49ers have beaten the Panthers the last two times they’ve met, including a 37-15 road win on Oct. 9, 2022, a game played 12 days before the McCaffrey trade.
This is a great NFL football matchup that you will not want to miss; make sure to tune in and catch all the action.
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