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Hidden mitochondrial DNA damage may be a missing link in disease
2025-11-28 04:29
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Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate stress-resp...
Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate stress-response pathways. Simulations show the damage makes mtDNA more rigid, possibly marking it for removal. The finding offers fresh clues to inflammation, aging, and diseases such as diabetes and neurodegeneration.
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